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Morphological Characteristics by Cell Implantation After Spinal Cord Injury in Infarction Region

Affiliations

  • Department of Health Administration, Namseoul University, Korea, Republic of
  • Department of Beauty and Health, Namseoul University, Korea, Republic of

Abstract


Objectives: Our research implanted stem cells to reduce behavioral deficiency in rodent animal models of clip compressive surgery inducing spinal cord infarction. Methods/Statistical Analysis: Non-transplanted control injection rats (n=10) were applied to spinal cord injury and administration of PBS (15 μl) after post-damage. Animals were injected with mESC implantation at the 5th day after injured surgery (n=20). Findings: We use the effect of grafted cell to the injured spinal cord region, focusing the use of mouse embryonic cells for regeneration of spinal cord infarction. These morphological characteristics postulated that mESC-graft could reduce the type of cavitations after damage in the SCI model. We also found that Schwann cell and glia cell contain numerous myelinated axons in the middle of the graft. Improvement/Applications: Our research suggests manifest result to prove that graft of stem cell could show behavioral improvement after spinal cord infarction.

Keywords

Clip-Compression, Embryonic Stem Cell, Graft, Infarction, Spinal Cord.

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References


  • Joshi M, Fehlings MG. Development and characterization of a novel, graded model of clip compressive spinal cord injury in the mouse. Journal of Neurotrauma. 2002 Feb; 19(2):175-90.
  • Myckatyn TM, Mackinnon SE. Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury. Transplant Immunology. 2004 Apr; 12(3-4): 343-58.
  • Setoguchi T, Nakashima K, Takizawa T, Yanagisawa M, Ochiai W, Okabe M, Yone K, Komiya S, Taga T. Treatment of spinal cord injury by transplantation of fetal neural precursor cells engineered to express BMP inhibitor. Experimental Neurology. 2004 Sep; 189(1):33-44.
  • Houle JD, Tessler A. Repair of chronic spinal cord injury. Experimental Neurology. 2003 Aug; 182(2):247-60.
  • Euler MV, Seiger A, Sundstrom E. Clip compression injury in the spinal cord: A correlative study of neurological and morphological alterations. Experimental Neurology. 1997 Jun; 145(2Pt1):502-10.
  • Basso DM, Murray M, Goldberger ME. Differential recovery of bipedal and over ground locomotion following complete spinal cord hemisection in cats. Restorative Neurology and Neuroscience. 1994 Jan; 7(2):95-110.
  • Ankeny DP, Mctigue MB, Jakeman LB. Bone marrow transplants provide tissue projection and directional guidance for axons after contusive spinal cord injury in rat. Experimental Neurology. 2004 Nov; 190(1):17-31.
  • Ohta M, Suzuki Y, Noda T, Ejiri Y, Dezawa M, Kataoka K, Chou H, Ishikawa N, Matsumoto N, Iwashita Y, Mizuta E, Kuno S, Ide C. Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Experimental Neurology. 2004 Jun; 187(2):266-78.
  • Kim DJ, Kim JH. Effect of the muscular strength exercise and massage on muscle injury marker and IGF. Indian Journal of Science and Technology. 2015 Oct; 8(27):1-5.
  • Mirzaei A, Rezanejad MT. Hepatoprotective effect and antioxidant activity of aqueous cherry extract on rats. Indian Journal of Science and Technology. 2015 Sep; 8(22):1-5.

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