Total views : 284

Design of Interface Circuit and Biosensor Fabrication using Inkjet Printer for the Detection of Glucose

Affiliations

  • Department of Electronics and Communication Engineering, Jawaharlal Nehru Technological University, Anantapuramu – 515002, Andhra Pradesh, India
  • Department of Electronics and Communication Engineering, Sree Vidyankethan Engineering College, Tirupati – 517102, Andhra Pradesh, India

Abstract


Objectives: The primary objective of this paper is to demonstrate the use of non conventional methods for printing of biosensors and development of appropriate electronic circuits and embedded systems for detection of glucose. Methods/Statistical analysis: Biosensor Fabrication requries clean room and high investment, In this paper, an attempt is made to design and fabricate biosensor using inkjet printer and the printed sensor is interfaced with signal conditioning and processing unit to detect change in the glucose concentration of the solution to be tested. Findings: Biosensors of various configurations have been modeled using online simulator and have been verified for their characteristics and properties based on software simulations. One of the key challenges in biosensor is fabrication process of biosensors.The serpentine and circular structures sensors are fabricatd and interfaced with signal conditioning circuit and controller. The patterns are printed using silvernitrate solution and the sensor is interfaced with wheatstone bridge and signal conditioning units. The sensing is carried out using reference circuit and the Analog-to-Digital Converter (ADC) circuit. Interface circuit and ADC is configured on Programmable System-on-Chip (PSOC) which are interfaced with Liquid Crystal Display (LCD) for display for readings. Application/Improvements: The circular designed biosensor is reliable than the serpentine structure and has more than 40% improvement in sensitivity in glucose detection.

Keywords

Biosensor, Glucose Detection, Ink Jet Printer, Serpentine and Circular Design.

Full Text:

 |  (PDF views: 244)

References


  • Sirvent MA, Merkoci A, Alegret S. Configurations used in the design of screen-printed enzymatic biosensors. A review. Sensors and Actuators B: Chemical. 2000 Sep 10; 69(1):153–63.
  • Wang T, Cook C, Derby B. Inkjet printing glucose oxidase for biosensor applications. Electro Chemical Society (ECS) Transactions. 2008 Oct 3; 16(11):15–20.
  • Martin GD, Hoath SD, Hutchings IM. Inkjet printing-the physics of manipulating liquid jets and drops. In Journal of Physics: Conference Serie, IOP. 2008; 105(1):012001.
  • Dua V, Surwade SP, Ammu S, Agnihotra SR, Jain S, Roberts KE, Park S, Ruoff RS, Manohar SK. All‐organic vapor sensor using inkjet‐printed reduced grapheme oxide. Angewandte Chemie. 2010 Mar 15; 122(12):2200–3.
  • Hossain SZ, Luckham RE, Smith AM, Lebert JM, Davies LM, Pelton RH, Filipe CD, Brennan JD. Development of a bioactive paper sensor for detection of neurotoxins using piezoelectric inkjet printing of sol− gel-derived bioinks. Analytical chemistry. 2009 Jun 3; 81(13):5474–83.
  • Jang J, Ha J, Cho J. Fabrication of water‐dispersible polyaniline‐poly (4‐styrenesulfonate) nanoparticles for inkjet‐printed chemical‐sensor applications. Advanced Materials. 2007 Jul 2; 19(13):1772–5.
  • Li B, Santhanam S, Schultz L, Jeffries-El M, Iovu MC, Sauvé G, Cooper J, Zhang R, Revelli JC, Kusne AG, Snyder JL. Inkjet printer chemical sensor array based on polythiophene conductive polymers. Sensors and Actuators B: Chemical. 2007 May 21; 123(2):651–60.
  • Azhir E, Etefagh R, Shahtahmasebi N, Mohammadi M, Amiri D, Sarhaddi R. Aspergillus Niger biosensor based on tin oxide (SnO2) nanostructures: nanopowder and thin film. Indian Journal of Science and Technology. 2012 July; 5(7):3010–2. Doi no:10.17485/ijst/2012/v5i7/30502.
  • Derby B. Bioprinting: inkjet printing proteins and hybrid cell-containing materials and structures. Journal of Materials Chemistry. 2008; 18(47):5717–21.
  • Setti L, Morgera AF, Ballarin B, Filippini A, Frascaro D, Piana C. An amperometric glucose biosensor prototype fabricated by thermal inkjet printing. Biosensors and Bioelectronics. 2005 Apr 15; 20(10):2019–26.
  • Saunders RE, Gough JE, Derby B. Delivery of human fibroblast cells by piezoelectric DOD. Biomaterials. 2008 Jan 31; 29(2):193–203.
  • Risio SD, Yan N. Piezoelectric ink‐jet printing of horseradish peroxidase: effect of ink viscosity modifiers on activity. Macromolecular Rapid Communications. 2007 Sep 18; 28(18–19):1934–40.
  • Nishioka GM, Markey AA, Holloway CK. Protein damage in drop-on-demand printers. Journal of the American Chemical Society. 2004 Dec 22; 126(50):16320–1.
  • Bishop DK, La Belle JT, Vossler SR, Patel DR, Cook CB. A disposable tear glucose biosensor—part 1: design and concept testing. Journal of Diabetes Science and Technology. 2010 Mar 1; 4(2):299–306.
  • Singh G, Bhalla A, Capalash N, Sharma P. Characterization of immobilized laccase from γ-proteobacterium JB: approach towards the development of biosensor for the detection of phenolic compounds. Indian Journal of Science and Technology. 2010 Jan; 3(1):48–53. Doi no: 10.17485/ijst/2010/v3i1/29643.
  • Oliver NS, Toumazou C, Cass AE, Johnston DG. Glucose sensors: a review of current and emerging technology. Diabetic Medicine. 2009 Mar 1; 26(3):197–210.
  • Cooper J, Cass T, editors. Biosensors. Oxford University Press, USA; 2004 Mar 4.
  • Jianrong C, Yuqing M, Nongyue H, Xiaohua W, Sijiao L. Nanotechnology and biosensors. Biotechnology Advances. 2004 Sep 30; 22(7):505–18.
  • Murthy KSN, Prasad GRK, Saikiran NLNV, Manoj TVS. Design and simulation of MEMS biosensor for the detection of tuberculosis. Indian Journal of Science and Technology. 2016 Aug; 9(31). Doi no:10.17485/ijst/2016/v9i31/90638
  • Wei A, Sun XW, Wang JX, Lei Y, Cai XP, Li CM, Dong ZL, Huang W. Enzymatic glucose biosensor based on ZnO nanorod array grown by hydrothermal decomposition. Applied Physics Letters. 2006 Sep 18; 89(12):123902.
  • Garcia Cordero JL. Development of innovative microfluidic polymeric technologies for point-of-care and integrated diagnostics devices [Doctor of Philosophy thesis]. Dublin City University; 2010 Apr.
  • Lowe CR. Overview of biosensor and bioarray technologies. Handbook of Biosensors and Biochips; 2007 Oct. p. 1500.
  • Liu Y, Matharu Z, Howland MC, Revzin A, Simonian AL. Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing. Analytical and Bio–Analytical Chemistry. 2012 Sep 1; 404(4):1181–96.
  • Newman JD, Turner AP. Historical perspective of biosensor and biochip development. Handbook of Biosensors and Biochips; 2008.
  • Lee KJ, Yun DH, Song MJ, Lee WJ, Hong SI. Nano-biosensor base on protected glucose oxidase nanoparticles. In 7th IEEE Conference on Nanotechnology (IEEE NANO); 2007 Aug 2. p. 578–82.
  • Zheng S, Lin H, Liu JQ, Balic M, Datar R, Cote RJ, Tai YC. Membrane micro filter device for selective capture, electrolysis and genomic analysis of human circulating tumor cells. Journal of Chromatography A. 2007 Aug 31; 1162(2):154–61.
  • Warren S, Vault JD. A biosignal acquisition and conditioning board as a cross-course senior design project. In 38th Annual Frontiers in Education Conference, IEEE; 2008 Oct 22. p. S3C–1.
  • Doherty RF, Pierry A. Inventors; Ocg Technology Inc., assignee. Signal conditioner for biological signals. United States patent US 4,540,000; 1985 Sep 10.
  • Kaushik K, Abhinit H, Harsh N, Rahul J. Design and prototyping of a biomimetic serpentine robot. Indian Journal of Science and Technology. 2016 Sep; 9(34):1–5. Doi no: 10.17485/ijst/2016/v9i34/100841
  • http://www.cypress.com

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.