Total views : 185
Determining the Optimal Dose of Radioactivity for Measuring Glomerular Filtration using Gate’s Method and Obtaining Renogram
Objectives: Measuring Glomerular Filtration (GFR) using Gate’s method gives low radioactivity of approximately 74~111 MBq to a patient. Such low counts on image acquisition degrade image quality. The objective of this study was to limit the amount of radioactivity needed to acquire high-quality dynamic renal images when measuring GFR. Methods/Statistical Analysis: We performed experiments with different radio activities at matrix size of 128 x 128 or other matrix sizes to check overflow phenomenon of gammaray. Findings: Ideal total count was at radioactivity of approximately 37 MBq. However, measured total counts from acquire images showed certain counting loss. The average margin of error was –1.88 ± 1.61%. The mean value of GFR according to the radioactivity at more than 370 MBq was –2.91 ± 1.19 %. We could calculate GFR by substituting these results in GFR formula under the same condition. The mean GFR value was –1.89 ± 1.62% at radioactivity of 37 MBq and –2.93±1.2 % at radioactivity of more than 370 MBq. Conclusion: High-quality functional image could be acquired at the same time by increasing radioactivity to 370 MBq with higher matrix size. Improvements/Applications: With these results, we can improve diagnostic ability and make more accurate evaluation of renal function.
Creatinine Clearance, GFR, Gate’s Method, Overflow Phenomenon, Renogram.
- Lee SR, Yoon SN, Lee BM, Oh CK, Kim SJ, Kim H, Shin GT. Changes of glomerular filtration rate of donated and remnant kidneys in a week after living donor kidney transplantation. Journal of Korean Society Transplant. 2006; 20(1):55–62.
- Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976; 16(1):31–41.
- Barbour GL, Crumb KC, Boyd CM, Reeves RD, Rastogi SP, Patterson RM. Comparison of inulin, iothalamate, and 99mTc-DMSA for measurement of glomerular filtration rate. Journal of Nuclear Medicine. 1976; 17(4):317–20.
- Shemesh O, Golbetz H, Kriss JP, Myers BD. Limitations of creative as a filtration marker in glomerulopathy patients. Kidney International. 1985; 28(5):830.
- Lee JK, Chun HK, Kim SJ, Lee SH, Yang CW, Kim YS, Choi EJ, Chang YS, Bang BK, Yang WJ, Chung SK. Clinical usefulness of GFR measured by 125I-iothalamte. Journal of Korean Medicine. 1995; 49(5):693–99.
- Taylor A. Radionuclide renography: a personal approach. Seminar Nuclear Medicine. 1999 Apr; 29(2):102–27.
- Gates GF. Glomerular filtration rate: estimation from fractional renal accumulation of 99mTc- DTPA (stannous). American Journal of Roentgenology. 1982 Mar; 138(3):565–70.
- Gates GF. Computation of glomerular filtration rate with 99mTc-DTPA: An in-house computer program. Journal of Nuclear Medicine. 1984 May; 25(5):613–8.
- Chachati A, Meyers A, Godon JP, Rigo P. Rapid method for the measurement of differential renal function: validation. Journal of Nuclear Medicine. 1987 May; 28(5):829–36.
- Tonnesen KH, Munck O, Hald T, Mogensen P, Wolf H. Influence on the renogram of variation in skin to kidney distance and the clinical importance thereof. Presented at the international symposium on radionuclides in nephrology. Berlin, April, 1974(Cited by Schlegel, JU, Hamway, SA: Individual renal plasma flow determination in 2 minutes). Journal of Urology. 1976; 116:282–85.
- Early PJ, Razzak MA, Soodee DB. Textbook of nuclear medicine technology, 3rd (edn)., St. Louis, Mosby. 1979; 115 pp.
- Kang YG. Textbook of Nuclear Medicine, 1rd (edn)., Chung-gu. 2013; 507–11.
- Taylor A, Lewis C, Giacometti A, Hall EC, Barefield KP. Improved formulas for the estimation of renal depth in adults. Journal of Nuclear Medicine. 1993 Oct; 34(10):1766–9.
- Blaufox MD, Aurell M, Bubeck B, Fommei E, Piepsz A, Russell C, Taylor A, Thomsen HS, Volterrani D. Report of the Radionuclide’s in Nephrourology Committee on renal clearance. Journal of Nuclear Medicine. 1996 Nov; 37(11):1883–90.
- GolChoe J, Baik SH, Lee MJ, Suk WH. Estimation of Glomerular Filtration Rate Using 99mTc-DTPA and Gamma Scintillation Camera. Journal of Korean Nuclear Medicine. 1992; 26(1):95–100.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.