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Micromagnetophoreses based CTCs Detections in Simple Chip

Affiliations

  • School of Life Science, Department of Biomedical Engineering, Beijing Institute of Technology, Beijing 100081, China
  • School of Life Science, Department of Pharmacy, Beijing Institute of Technology, Beijing 100081, China

Abstract


Rare cells separation as in Circulating Tumor Cells (CTCs) from clinical blood sample has fetal importance in cancer monitoring and treatment. Here we study a method of CTCs separation from clinical sample or buffer sample by magnetic separation technique. Design and simulations of magnetic and drag forces in the microchannel for separation of magnetic particles and CTCs have been studied. Modeling software COMSOL Multiphysics 4.3a (COMSOL, Inc.) which uses finite element method used to design and simulation of the microchannels device for the characterization the device. The simulation was done in two stages first for magnetic field generated from the permanent magnet positioned at a specific distance from the microchannel wall and second the cell/particle tracing for cell separation verifications. The separation results with 93% purity and efficiency of the undesired particle was achieved 0.105m/s velocity and cancer cells size about 15 μm. Considering the results achieved, our proposed microchannel device is a good candidate for cancer cells detections in clinical uses.

Keywords

Cancer Cell, Computational Fluid Dynamics, Magnetophoresis, Microfluidics

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