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Study on the Effects of Electrode and Microchannel Sizes on the Performance of MBEB
Background/Objectives: The design and fabrication of Microfluidics-based electrochemical biosensor with high quality and the optimal effective surface area are of primary importance for more accurate result. The effects of the microelectrode size with variation in the microchannel size was investigated. Methods/Statistical Analysis: The effect of the microchannel size on the performance of the sensor was then investigated using cyclic voltammetry testing for different sizes of the fabricated channels (100, 400, 700 and 1000 μm) at electrode size of 100μm and 200μm. Findings: The electrokinetic properties of the microchannel were found to be affected by the size of both the microchannel and the electrode. The highest sensitivity of the sensor was reported at microchannel size of 700 and electrode size of 200μm. Application/Improvements: High accuracy and fast responding electrochemical biosensor are expected to be produced through the optimization of the microchannel size and the electrode surface area.
Microfluidics, Electrochemical Biosensor, Microscope, Microchannel, Electrode.
- Cao J, Sun T, Grattan KTV. Gold nanorod-based localized surface plasmon resonance biosensors: A review.Sensors and Actuators B: Chemical. 2014; 195:332–51.
- Gomez FA. Biological applications of microfluidics: John Wiley & Sons. 2008.
- Gopinath PG, Aruna Mastani S, Anitha VR. Design of Interface Circuit and Biosensor Fabrication using Inkjet Printer for the Detection of Glucose. Indian Journal of Science and Technology. 2016 Dec; 9(15):1–15.
- Kim J, Junkin M, Kim D-H, Kwon S, Shin YS, Wong PK et al. Applications, techniques, and microfluidic interfacing for nanoscale biosensing. Microfluidics and Nanofluidics. 2009; 7(2):149–67.
- Zhang X, Jones P, Haswell SJ. Attachment and detachment of living cells on modified microchannel surfaces in a microfluidic-based lab-on-a-chip system.Chemical Engineering Journal. 2008; 135(1):S82–S88.
- Abad L, Javier del Campo F, Munoz FX, Fernandez LJ, Calavia D, Colom G et al. Design and fabrication of a COP based microfluidic chip: Chronoamperometric detection of Troponin T. Electrophoresis. 2012 Nov; 33(21):3187–94.
- Lamberti F, Luni C, Zambon A, Serra PA, Giomo M, Elvassore N. Flow biosensing and sampling in indirect electrochemical detection. Biomicrofluidics. 2012; 6(2):24114–1413.
- Heo J, Crooks RM. Microfluidic biosensor based on an array of hydrogel-entrapped enzymes. Analytical chemistry. 2005 Nov; 77(21):6843–51.
- Chen I-J, White IM. High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode. Biosensors and Bioelectronics. 2011 Jul; 26(11):4375–81.
- Hayder AA, Esmail AB. Investigating the Effects of Microchannel Size on the Performance of MicrofluidicsBased Electrochemical Biosensor. Current Analytical Chemistry. 2016; 12:1.
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