Total views : 195
Preliminary Study on Operating Parameters toward the Metastable Zone-Width of Carbamazepine Co-Crystal
Objectives: Metastable zone width (MSZW) is a crucial parameter in designing co-crystallization process in order to achieve required crystal habits. The effects of operating parameters toward metastable zone width of carbamazepine-saccharin (CBZ-SAC) co-crystal were studied in this research. Methods/Statistical Analysis: Crystallization study was conducted using cooling crystallization method which involves polythermal method. A 250 ml scale size-reactor was used to study the effects of operating parameters on metastable zone width of CBZ-SAC co-crystal which tested with various mol ratio of SAC/CBZ, concentration of CBZ, cooling and heating rates and stirring speeds. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD) and optical microscopy were applied to characterize the CBZ-SAC co-crystals. Findings: The results show that MSZW decreases as the mol ratios of SAC/CBZ increases, whilst also decreases with CBZ concentrations, cooling rates and stirring speeds. Application/Improvements: Cooling crystallization process is extensively used in the manufacture of pharmaceutical drugs.
Co-Crystal, Metastable Zone Width, Nucleation Kinetics, Polythermal Method.
- Mullin JW. Oxford: Butterwort-Heinemann: Crystallization, 4th (edn). 2001.
- Sangwal K. Novel approach to analyze metastable zone width determined by the polythermal method: physical interpretation of various parameters. Crystal Growth and Design. 2009; 9(2):942-50. Crossref
- Kubota N. A unified interpretation of metastable zone widths and induction times measured for seeded solutions. Journal of Crystal Growth. 2010; 312:548-54. Crossref
- Bogacz W, Wojcik J. The metastable zone of aqueous solutions. Chemik. 2014; 68(3):198-201.
- Jin M, Frohberg P, Sun Y, Li P, Yu J, Ulrich J. Study on metastable zone width and crystal growth of a ternary system: case study MgCl2 . 6H2O.1, 4-dioxane. Chemical Engineering Science. 2015; 133:181-9.
- Mohammad KA, Abd Rahim S, Abu Bakar MR. Nucleation kinetics of carbamazepine-saccharin (CBZSAC) Co-Crystal. International Conference on Global Sustainability and Chemical Engineering (ICGSE). 2014.
- Anuar N, Wan Daud WR, Roberts KJ, Kamarudin SK, Tasirin SM. An examination of the solution chemistry, nucleation kinetics, crystal morphology, and polymorphic behavior of aqueous phase batch crystallized L-Isoleucine at the 250 mL scale size. Crystal Growth and Design. 2009; 9(6):2853-62. Crossref
- Liu X, Wang Z, Duan A, Zhang G, Wang X, Sun Z, Zhu L, Yu G, Sun G, Xu D. Measurement of L-arginine trifluoroacetate crystal nucleation kinetics. Journal of Crystal Growth. 2008; 310(10):2590-92.
- Rodriguez-Hornedo N, Nehm SJ, Seefeldt KF, Pagan-Tores Y, Falkiewicz JC. Reaction crystallization of pharmaceutical molecular complexes. Molecular Pharmaceutical. 2006; 3(3):362-7. Crossref PMid:16749868
- Mitchell NA, Frawley PJ. Nucleation kinetics of paracetamolethanol solutions from metastable zone widths. Journal of Crystal Growth. 2010; 312(19):2740-46. Crossref
- Ni X, Liao A. Effects of cooling rate and solution concentration on solution crystallization of l-glutamic acid in an oscillatory baffled crystallizer. Crystal Growth and Design. 2008; 8(8):2875-81. Crossref
- Kitamura M. In situ observation of growth process of ά-LGlutamic acid with atomic force microscopy. Journal of Colloid and Interface Science. 2000; 224(2):311-6. Crossref PMid:10727341
- Hussain K, Thorsen G, Malthe-Sorenssen D. Nucleation and metastability in crystallization of vanillin and ethyl vanillin. Chemical Engineering Science. 2001; 56(1):2295304. Crossref
- Kubota N. An interpretation of the metastable zone width concerning primary nucleation in anti-solvent crystallization. Journal of Crystal Growth. 2008; 310:4647-51.Crossref
- Zou F, Zhuang W, Wu J, Zhou J, Yang P, Liu Q, Chen Y, Ying H. Determination of metastable zone widths and the primary nucleation and growth mechanisms for the crystallization of disodium guanosine 5'-monophosphate from a water-ethanol system. Industrial and Engineering Chemistry Research. 2015; 54:137-45. Crossref
- Liang K, White G, Wilkinson D. Examination of the process scale dependence of l-glutamic acid batch crystallized from supersaturated aqueous solutions in relation to reactor hydrodynamics. Industrial and Engineering Chemical Research. 2004; 43:1227-34. Crossref
- Lee MJ, Wang IC, Kim MJ, Kim P, Song KH, Chun NH, Park HG, Choi GJ. Controlling the polymorphism of carbamazepinesaccharin cocrystals formed during antisolvent cocrystallization using kinetic parameters. Korean Journal Chemical Engineering. 2015; 32(9):1910-17. Crossref
- Porter III WW, Elie SC, Matzger AJ. Polymorphism in carbamazepine cocrystals. Crystal Growth and Design. 2008; 8:14-6. Crossref PMCid:PMC2668533
- Abd Rahim S, Hammond RB, Sheikh AY, Robert KJ. A comparative assessment of the influence of different crystallization screening methodologies on the solid forms of carbamazepine co-crystals. CrystEngComm. 2013; 15:3862-73. Crossref
- Kudo S, Takiyama H. Production method of carbamazepine/ saccharin cocrystal particles by using two solution mixing based on the ternary phase diagram. Journal of Crystal Growth. 2014; 392:87-91. Crossref
- Hickey MB, Peterson ML, Scoppettuolo LA, Morrisette LS, Vetter A, Guzman H, Remenar JF, Zhang Z, Tawa MD, Haley S, Zaworotko MJ, Almarsson O. Performance comparison of a co-crystal of carbamazepine with marketed product. European Journal of Pharmaceutics and Biopharmaceutics. 2007; 67:112-9. Crossref PMid:17292592
- Liszi I, Hasznos-Nezdei M, Farkas B. Effect of mixing on primary nucleation. Hungarian Journal of Industry and Chemistry. 1997; 25(3):181-4.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.