Total views : 325
Early Detection of Down Syndrome Marker by Measuring Fetal Nuchal Translucency Thickness from Ultrasound Images during First Trimester
Objectives: Nuchal Translucency (NT) thickness measurement is a Down syndrome marker for chromosomal abnormalities which is detected by non-invasive test during first trimester. Methods: In this paper, a computerized method to measure NT thickness is proposed. It consists of region of interest extraction, NT segmentation using morphological operation with Otsu thresholding. The NT thickness is measured from the segmented area. The performance is analyzed on 80 ultrasound fetal images. Findings: Proposed approach for NT measurement is implemented in MATLAB software. Experimental results show that NT thickness for normal foetus is 1.99±.62 mm and abnormal foetus is 4.10±.90 mm during first trimester of pregnancy from 11 to 13+6 weeks of gestation. The proposed algorithm efficiently computes NT measurement and produces consistent result during first trimester in singleton pregnancies. Applications/Improvements: Proposed semi-automated technique helps the medical sonographer for accurate NT thickness measurement to detect Down syndrome marker during first trimester ultrasound scan.
Down Syndrome, Morphological Operation, Nuchal Translucency, Trimester, Thresholding.
- Kagan KO, Wright D, Valencia C, Maiz N, Nicolaides KH. Screening for trisomy’s 21, 18 and 13 by maternal age, fetal nuchal translucency, fetal heart rate, free beta-hCG and pregnancy-associated plasma protein-A. Human Reproduction. 2008 Sep; 23(9):1968–75.
- Snijders RJM, Noble P, Sebire N, Souka A, Nicolaides KH. UK multicentre project on the assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Lancet. 1998 Aug; 352(9125):336–7.
- Muller MA, Pajkrt E, Bleker OP, Bonsel GJ, Bilardo CM. Disappearance of enlarged nuchal translucency before14 weeks gestation relationship with chromosomal abnormalities and pregnancy outcome. Ultrasound in Obsteterics Gynecology. 2004 Aug; 24(2):169–74.
- Snijders RJM, Nicolaides KH. Sequential screening. In: Nicolaides KH, editor. Ultrasound markers for fetal chromosomal defects. Carnforth, UK: Parthenon Publishing; 1996. p. 109–13.
- Elahifar MA, Hasanzadeh M, Dahmardeh H, Elahifar A. The relationship between thickness of nuchal translucency and down syndrome in the first trimester of pregnancy. Zahedan Journal of Research in Medical Sciences. 2012 Jun; 14(4):26–8.
- Souka AP, Krampl E, Bakalis S, Heath V, Nicolaides KH. Outcome of pregnancy in chromosomally normal fetuses with increased nuchal translucency in the first trimester , Ultrasound Obsteterics & Gynecology, 2001 Jul , 18(1), pp. 9–17.
- Casals E, Aibar C, Martinez J M, Borrell A, Soler A, Ojuel J, Ballesta A M, Fortuny A. First-trimester biochemical markers for Down syndrome , Prenatal Diagnosis, 1999 Jan, 19(1), pp. 8–11.
- Wee L K, Min T Y, Arooj A, Supriyanto E. Nuchal translucency marker detection based on artificial neural network and measurement via bidirectional iteration forward propagation. WSEAS Transactions on Information Science and Applications. 2010 Aug; 7(8):1025–36.
- Nirmala S, Palanisamy V. Measurement of nuchal translucency thickness for detection of chromosomal abnormalities using first trimester ultrasound fetal images. International Journal of Computer Science and Information Security (IJCSIS). 2009 Dec; 6(3):101–6.
- Deng Y, Wang Y, Chen P. Automated detection of fetal nuchal translucency based on hierarchical structural model. IEEE International Symposium on Computer-Based Medical Systems (CBMS); Perth, WA. 2010 Oct. p. 78–84.
- Moratalla J, Pintoffl K, Minekawa R, Lachmann R, Wright D, Nicolaides KH. Semi-automated system for measurement of nuchal translucency thickness. Ultrasound in Obsteterics and Gynecology. 2010 Oct; 36(4):412–6.
- Park JH, Sofka M, Lee SM, Kim DY, Zhou SK. Automatic nuchal translucency measurement from ultrasonography. Medical Image Computing and Computer-Assisted Intervention-MICCAI. Springer-Verlag: Berlin Heidelberg; 2013; 16(Pt 3):243–50.
- Wee LK, Chai HY, Supriyanto E. Computerized nuchal translucency three dimensional reconstruction, visualization and measurement for trisomy 21 prenatal early assessment. International Journal of the Physical Sciences. 2011 Sep; 6(19):4640–8.
- Cho HY, Kwon JY, Kim YH, Lee KH, Kim J, Kim SY, Park YW. Comparison of nuchal translucency measurements obtained using Volume NT(TM) and two- and three-dimensional ultrasound. Ultrasound in Obsteterics Gynecology. 2012 Feb; 39(2):175–80.
- Mahale N, Kumar A, Rayapureddi VCM, Mahale A, Krishnapriya. Variation of nuchal translucency with increasing crown rump length and gestational age in normal singleton pregnancies. IOSR Journal of Dental and Medical Sciences. 2013 May-Jun; 6(3):16–9.
- Anitha U, Malarkkan S. A novel approach for despeckling of sonar image. Indian Journal of Science and Technology. 2015 May; 8(S9):252–9.
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.