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Issue No:6, Vol.3 |
June - 2010 |
ISSN: 0974-5645 |
| RESEARCH ARTICLES |
Viewers & PDF |
| 8. Clastogenic effect of sodium arsenite in experimental rats and ameliorative effects of antioxidant vitamins C and E.B.S. Balakumar, S. Kumaresan, R. Venugopal and V. Sivasubramanian (2010) Indian J.Sci.Technol. Vol. 3, Issue 6, pp: 642-647. Domain site: http://www.indjst.org. |
 
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- Abstract
Arsenic, an element ubiquitous in the environment, causes serious health problems in humans. The general population
is more exposed to arsenic through drinking water than through air and food. Sodium arsenite, capable of inducing
genotoxic effects through oxidative stress, is evaluated for its clastogenic effect by the formation of chromosomal
aberrations in the bone marrow cells of Wistar rats. We also investigated whether the oral supplementation of α–
tocopherol (400 mg/kg body weight) and ascorbic acid (200 mg/kg body weight) to arsenic–intoxicated rats (100 ppm in
drinking water) for 30days, ameliorates arsenic-induced toxicity. We report that the dietary supplementation of
antioxidants such as vitamins C and E could prevent sodium arsenite induced toxicity in rats under experimental
conditions.
- Keywords: Arsenic, genotoxicity, ascorbic acid, α-tocopherol, chromosomal aberrations, vitamins, rat, bone marrow.
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