Indian Journal of
Science and Technology
 
 
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Issue No:3, Vol.3
March - 2010
ISSN: 0974-5645
RESEARCH ARTICLES Viewers & PDF
7. Studies on adsorption of diphtheria toxoid on aluminium phosphate gel. N. Sivananda and B. Sundaran (2010). Indian J.Sci.Technol. Vol. 3, Issue 3, pp: 248-249. Domain site: http://www.indjst.org

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  • Abstract
    Aluminium compounds are widely used as an adjuvant in Diphtheria, Tetanus, and Pertussis (DPT) group of vaccines. Diphtheria and tetanus toxoids are adsorbed on aluminium phosphate gel and used in the immunization. Generally a plain vaccine is less immunogenic. After adsorption it will have a repositary action. The present study envisages the adsorption rate of diphtheria toxoid on aluminium phosphate gel at different pH (5.0, 6.0, 6.5, 7.0 and 7.5). The main
    conclusion drawn from the experiments is that the low pH favours high adsorption rate.
  • Keywords: Diphtheria toxoid; aluminium phosphate gel, adsorption, vaccine.