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Issue No:9 Vol.3 |
September - 2010 |
ISSN: 0974-5645 |
| RESEARCH ARTICLES |
Viewers & PDF |
| 4. Formulation of ferrous fumarate (combination) tablets by using a direct-compression method. Kishwar Sultana, Najm ul Hassan, M. Shifa khan, Mohsin Abbas khan, Khadija Shahid, Humaira Nadeem and Junaid Umar Alvi. Indian J.Sci.Technol. Vol. 3, Issue 8, pp: 994-1000. Domain site: http://www.indjst.org. |
 
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- Abst ract
Ferrous fumarate has poor flow properties which cause compression problems. When ferrous fumarate is
manufactured in combination with folic acid, the same problem is encountered. Therefore, a wet-granulation method is
used for tablet manufacturing, which is a time-consuming and energy-wasting process compared to a directcompression
method. In the present work, ferrous fumarate and folic acid (combination) tablets have been prepared
using an optimized direct-compression technique that decreases the total manufacturing time of a batch (approx. 1.5
million tablets) from 24-28 h to only 2–3 h. The direct-compression technique is a simple and cost-effective method of
manufacturing ferrous fumarate and folic acid (combination) tablets. Several formulations were developed using
different proportions of avicel PH102, talcum, magnesium stearate, sodium lauryl sulfate, sugar, primojel, lactose,
PVPK-30 and aerosil. Ten formulations were found to fulfill the specified criteria.
- Keywords: Ferrous fumarate, folic acid, tablets, direct compression, combination.
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